Erythrocyte polyunsaturated fatty acid levels in young people at ultra-high risk for psychotic disorder and healthy adolescent controls

SM Rice; MR Schäfer; C Klier; N Mossaheb; N Vijayakumar; GP Amminger

Journal article

Erythrocyte polyunsaturated fatty acid levels in young people at ultra-high risk for psychotic disorder and healthy adolescent controls

SM Rice, MR Schäfer, C Klier, N Mossaheb, N Vijayakumar, GP Amminger

Psychiatry Research | ELSEVIER IRELAND LTD | Published : 2015

DOI: 10.1016/j.psychres.2015.04.036

Abstract

Erythrocyte polyunsaturated fatty acid (PUFA) levels from individuals at ultra-high risk (UHR) for psychosis (n=80) were compared to existing data from healthy controls (n=142). Results demonstrated PUFA deficits (α-linolenic acid, eicosapentanoic acid, all ω-6 PUFAs) for the UHR group. Findings provide a rationale for PUFA based interventions in emerging psychosis.

University of Melbourne Researchers

Simon Rice Author

Nandita Vijayakumar Author

Paul Amminger Author

Related Projects (1)

LIPID BIOLOGY FOR PREDICTION AND PREVENTION OF PSYCHOTIC DISORDERS AND PERSISTENT DEPRESSION IN YOUNG PEOPLE

My vision for the next 5 years is to establish ω-3PUFAs as a first-line treatment for indicated prevention of psychosis and persistent depre..

Grants

Awarded by Stanley Medical Research Institute

Funding Acknowledgements

This work was supported by grants from the Stanley Medical Research Institute (03T-315 and 07TGF-1102). GPA is supported by a NHMRC Senior Research Fellowship 1080963. The authors particularly wish to thank all of the young people who took part in the study.